Effects of combined 5-HT2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice.

RATIONALE: Prepulse inhibition of the startle reflex (PPI) is disrupted in several psychiatric disorders including schizophrenia. Understanding PPI pharmacology may help elucidate the pathophysiology of these disorders and lead to better treatments. Given the advantages of multi-target approaches for complex mental illnesses treatment, we have investigated the interaction between receptors known to modulate PPI (5-HT1A and 5-HT2A) and the neuromodulatory endocannabinoid system. OBJECTIVES: To investigate serotonin and cannabinoid receptor (CBR) co-modulation in a model of PPI disruption relevant to schizophrenia METHODS: Male Swiss mice were pretreated with WIN 55,212-2 (CBR agonist), rimonabant (CB1R inverse agonist), 8-OH-DPAT (5-HT1A/7 agonist), and volinanserin (5-HT2A antagonist) or with a combination of a cannabinoid and a serotonergic drug. PPI disruption was induced by acute administration of MK-801. RESULTS: WIN 55,212-2 and rimonabant did not change PPI nor block MK-801-induced deficits. 8-OH-DPAT increased PPI in control mice and, in a higher dose, inhibited MK-801-induced impairments. Volinanserin also increased PPI in control and MK-801-treated mice, presenting an inverted U-shaped dose-response curve. Co-administration of either cannabinoid ligand with 8-OH-DPAT did not change PPI; however, the combination of volinanserin with rimonabant increased PPI in both control and MK-801-exposed mice. CONCLUSIONS: WIN 55,212-2 and rimonabant had similar effects in PPI. Moreover, serotonin and cannabinoid receptors interact to modulate PPI. While co-modulation of CBR and 5-HT1A receptors did not change PPI, a beneficial effect of 5-HT2A and CB1R antagonist combination was detected, possibly mediated through potentiation of 5-HT2A blockade effects by concomitant CB1R blockade.

Allergic recurrent coronary stent thrombosis: A mini-review of Kounis syndrome.

Kounis syndrome (KS) consists of an association between hypersensitivity reactions triggered by various environmental and pharmacological factors and acute coronary syndromes. Blood supply may be compromised by either vasospasm (type I), native plaque destabilization (type II) or stent thrombosis (type III). Although the prognosis is generally favorable, treatment should include aggressive anti-thrombotic and anti-allergic therapies. A case compatible with type III KS, manifested as a macular rash followed by two episodes of stent thrombosis after primary angioplasty (PCI) of the right coronary artery is presented, and complemented by a review on the topic.

Acompanhamento por telefone no pós-alta dos pacientes onco-hematológicos: revisão integrativa da literatura / Seguimiento por teléfono de pacientes onco-hematológicos después de alta hospitalaria: revisión integrativa de la literatura / Phone follow-up of onco-hematology patients’ post-discharge: integrating review of literature

Objetivo: analisar a produção científica acerca do acompanhamento, por telefone, pelo enfermeiro, no pós-alta do paciente com doença onco-hematológica, na redução do evento de readmissão hospitalar. Método: trata-se de uma revisão integrativa da literatura. Tal revisão visa responder à seguinte questão de pesquisa: A intervenção no acompanhamento por telefone, pelo enfermeiro, no pós-alta, reduz a readmissão hospitalar dos pacientes com doença onco-hematológica? A pesquisa foi realizada nasseguintes bases de dados: Cochrane Library, PubMed, LILACS e CINAHL. A busca foi iniciada no segundo semestre de 2016 e finalizada em fevereiro de 2017, sem qualquer restrição quanto a idioma e período. Após a análise das publicações, foram selecionados para compor a amostra da pesquisa, seis artigos, que foram submetidos à análise de conteúdo. Resultados: Foram elaboradas duas categorias temáticas: benefícios e desvantagens da consulta através do acompanhamento por telefone realizada pelo enfermeiro-oncologista; elementos necessários à avaliação, pelo enfermeiro durante o acompanhamento por telefone. Conclusão: A intervenção telefônica tem sido um instrumento de trabalho do enfermeiro, que possibilita estar mais próximo ao paciente, quando este se encontra geograficamente longe e mais necessitado de um cuidado que lhe forneça segurança, conforto e qualidade de vida.

Objective: to analyze the scientific production about the telephone follow-up by the nurse in the post-discharge of oncohematologicaldisease patients, in the reduction of the hospital readmission event. Method: this is an integrating review ofliterature. This review aims to answer the following research question: Does intervention in the telephone follow-up by the nurse inthe post-discharge period reduce the hospital readmission of patients with onco-hematological disease? The research was carriedout in the following databases: Cochrane Library, PubMed, LILACS and CINAHL. The search began in the second half of 2016 andended in February 2017 without any restriction on language and period. After the publications analysis, six articles were selected tocompose the research sample and were submitted to content analysis. Results: The study elaborated two thematic categories:benefits and disadvantages of the consultation through the telephone follow-up performed by the oncologist nurse and necessaryelements for evaluation by the nurse during the telephone follow-up. Conclusion: The telephone intervention has been nurse’s toolthat makes it possible to be closer to the patient when this one is geographically far away and needs more care to provide safety,comfort and quality of life.

Objetivo: analizar la producción científica sobre el seguimiento telefónico por los enfermeros después de alta hospitalaria de lospacientes con enfermedades onco-hematológicas, en la reducción de eventos de reingreso hospitalario. Método: Se trata de unarevisión integrativa de la literatura. Esta revisión tiene como objetivo responder a la siguiente pregunta de investigación: ¿Laintervención en acompañamiento por teléfono, por los enfermeros, después de altas hospitalarias reduce el reingreso de lospacientes con enfermedad onco-hematológica? La encuesta se llevó a cabo en las siguientes bases de datos: Cochrane Library,PubMed, LILACS y CINAHL. La búsqueda se inició en la segunda mitad de 2016 y terminó en febrero de 2017 sin restricciones en elidioma y el período. Después de revisar la literatura, fueron seleccionados para la muestra de la encuesta, seis artículos que fueronsometidos a análisis de contenido. Resultados: dos categorías temáticas se elaboraron: ventajas y desventajas de la consultatelefónica de seguimiento realizada por el oncólogo enfermero; elementos necesarios para la evaluación, por parte del enfermerodurante el seguimiento por teléfono. Conclusión: La intervención telefónica ha sido una herramienta de trabajo que permite elenfermero estar más cerca del paciente, si está geográficamente lejos y necesita cuidado que le proporciona seguridad, comodidady calidad de vida.